
5
Social and Structural Determinants
Women’s health depends on social and structural determinants. Research and innovation should address root causes, intersectional impacts, and context; use frameworks like syndemic care; measure determinants; and show societal benefits. Funders must back equitable, culturally relevant, actionable solutions for SGM, women of color, and LMIC populations.

Social and structural determinants of health are the factors that shape the conditions in which people live.
These include social, economic, and legal forces, systems, and policies that determine opportunities and access to high-quality jobs, education, housing, transportation, built environment, information and communication infrastructure, food, and healthcare; the social environment; and other conditions of daily life. Individual factors such as race, ethnicity, gender identity/expression, disability status, veteran status, and age also significantly influence health outcomes. These contextual factors significantly affect the health of all women. Global and national research agendas should address both the root causes of disparities and inequities and the impact of social and structural determinants on women’s health, including community-level factors, such as cultural norms and practices. They should also consider the intersectional nature and compounding effects of these factors on women, such as the effect of gender roles and race together on health status. Upstream R&D practices can better integrate these factors in women’s health innovations and measure their broader impact on communities and societies.

Women’s health innovations focused solely on individual behavior change or treatments may not address the underlying social and structural factors contributing to poor health outcomes.
Furthermore, ignoring the historical context and root causes of inequity may limit the impact potential of innovations and research. By addressing these factors, researchers can develop interventions that are more likely to improve women’s health outcomes in the long term and advance health equity among all women, including adolescent and post-menopausal women, women from low- and middle-income countries (LMICs), sexual and gender minority (SGM) populations, and women of color. New frameworks such as syndemic care models—which study diseases alongside socio-economic status, health system infrastructure, traditional and cultural contexts, and more—can help. By prioritizing social and structural determinants in women’s health innovation, researchers and funders can more comprehensively understand the root causes of health disparities and inequities and develop effective interventions to address them. Researchers must also demonstrate to funders the wide-ranging benefits of new interventions—financial return on investment and impact—for women and for societies. This starts with measuring the social and structural factors that affect women.
The featured opportunities call for women’s health innovation to account for and address the social contexts that promote or worsen women’s health and rights. Innovators must actively consider social and structural factors to develop contextually relevant interventions for all women, including SGM populations and people assigned female at birth. The leading opportunities do not address all factors that impact women’s health; they are designed to be actionable, not just aspirational. Partners should support the introduction of more equitable, sustainable, and culturally appropriate women’s health solutions by addressing root causes of inequities and elevating diverse populations of women at all stages of the R&D continuum.
Overview Social and Structural Determinants
5.1 Women’s needs in research agendas
It is essential to recognize that women are not a monolithic group. Research agenda-setting exercises must ensure that all women’s voices are heard and that the voices of women who have historically been disempowered (e.g., people of color, SGM populations, women with disabilities, and women who represent intersections of identities) are elevated. This may take many forms, from ensuring representation as decision-makers in crafting policies that impact women’s health to sourcing and recognizing women’s needs from sources beyond peer-reviewed medical journals.
Progress Assessment
Progress made against Opportunities, from the 2024 Progress Report
Status Moderate Progress
0 % Achievement

Solution Strategies
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Advocate for public and private funders to identify and engage diverse populations in every stage of every project, from planning to dissemination, such as through requests for proposals requirements. Ensure that engaged populations have power to shape the projects in which they are involved.
5.2 SDOH interventions
Populations of women that are unhoused, from rural areas, immigrants/refugees, low-income, and face language/cultural differences, among other life circumstances and identities, face compounding factors that impact their health outcomes. Comprehensive interventions often incorporate social and structural components that improve health outcomes beyond medical treatment courses. Social determinants must be included as part of research studies on women’s health. For example, when conducting research in cardiovascular disease, in addition to including the typical risks and co-morbidities such as obesity and hypertension, measurements of social determinants should also be included, such as socio-economic status, education and health literacy, stress and mental health, workload and time constraints, and access to healthcare.
Progress Assessment
Progress made against Opportunities, from the 2024 Progress Report
Status Moderate Progress
0 % Achievement

Solution Strategies
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Curate and collect current reviews on SDOH interventions from various journals, associations, and researchers. Since relevant evidence may exist outside peer-reviewed journals, seek completed interventions and evaluations that were published without peer-review.
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Convene partners globally to discuss the curated data review, focusing on interventions that work or do not work to inform women’s health outcomes, and develop equitable standards for inclusion of social determinants of health in women’s health research.
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Develop a widely accessible data repository or library of resources on SDOH interventions and best practices. Identify and disseminate key findings beyond traditional methods (i.e., medical journals), such as through conferences, storytelling, art, and social media.
5.3 Research intersectional impacts on WH
Structural and systemic factors affect women’s economic agency, such as discrimination and bias, education barriers, unpaid caretaking for children and older people, and social and cultural norms—all of which impact women’s economic choices, access, opportunities, and health outcomes. For example, traditional gender roles may assign women primary responsibility for caregiving and household duties, leading to increased stress, mental health issues, and reduced access to healthcare services. Studies have shown that gender norms influence health-related behaviors, such as care-seeking and weight control, as well as exposure risk, such as to sexual or physical intimate partner violence. These gendered expectations can also limit women’s autonomy and decision-making power regarding their own health. Understanding the prevailing gender roles in a specific context and having global perspectives and contextual variations on gender roles and women’s health is crucial for examining their impact on women’s health. Furthermore, research and interventions that address intersections of different systems of oppression are more likely to have the desired health impacts.
Progress Assessment
Progress made against Opportunities, from the 2024 Progress Report
Status Moderate Progress
0 % Achievement

Solution Strategies
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Develop standards and guidelines to identify, engage, and address gender norms through a consultative process.
- Convene women from different countries and regions to inform the standards.
- Conduct a comparative study across countries to compare and contrast the impact of gender roles, power dynamics, and economic agency on women’s health across different countries and cultural contexts.
- Conduct longitudinal studies that follow women across time and comparative studies across different regions to understand the long-term impacts of gender roles and economic agency and their intersections on women’s health.
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Develop validated measures of economic agency, unpaid labor, and caregiving burden on women’s health through a consultative process that includes diverse groups of women and men to ensure it is a transformative approach with broad buy-in.
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Examine the impacts of digitalization, technological advancements, and access to digital platforms on women’s economic agency, empowerment, and health outcomes through research on digital platforms/technologies and their potential to enhance economic opportunities, empower women economically, and promote better health outcomes.
5.4 Women’s representation in research grant reviews
Women who have been historically disempowered, stigmatized, disinvested, and understudied should be better represented in the review process, particularly when grant-making agencies and funders are considering research grants that impact these populations. Adequate understanding or appreciation of the health and social contexts of these groups will allow for appropriate consideration of their needs and an informed evaluation of relevant projects. This could have important implications for the volume and quality of supported R&D research on the health of women made vulnerable by their identity or social contexts. For example, reviewers of SGM health research projects should be able to acknowledge and include SGM perspectives and considerations and to speak adequately on these topics in review panels.
Progress Assessment
Progress made against Opportunities, from the 2024 Progress Report
Status Unchanged Progress
0 % Achievement

Solution Strategies
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Increase representation on grant review panels by forming external auxiliary bodies (e.g., advisory boards) composed of individuals with specific lived experience and/or expertise (e.g., SGM populations). The auxiliary bodies, tailored to the relevant research needs, should be empowered to veto studies that are not culturally appropriate or congruent and rescue proposals that were not recommended for funding due to a lack of relevant expertise and experience among prior reviewers.
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Provide intentional and focused training for members of marginalized communities to be reviewers. Disseminate tailored or adapted training so private or community groups can use it.
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Develop standards for recruitment based on lived experience and/or research experience with marginalized communities (e.g., SGM populations or racial and ethnic minorities) and expertise in the field via expert panel sessions or change advisory boards.
5.5 Traditional and cultural practices for WH
In some cases, traditional cultural practices (e.g., female genital mutilation) compromise women’s health and well-being. However, other cultural practices (traditional food, social structures and support, doulas and birth attendants, massage) may promote women’s health outcomes and well-being. Women’s health stakeholders should recognize negative connotations and biases around traditional, cultural, and spiritual practices. They should seek to understand, test, and elevate efficacious and safe practices rather than stigmatize them. By intentionally studying and incorporating traditional and cultural practices into medical standards of care, women can have an improved, contextually appropriate experience of care.
Progress Assessment
Progress made against Opportunities, from the 2024 Progress Report
Status Unchanged Progress
0 % Achievement

Solution Strategies
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Identify current safe and efficacious traditional, cultural, and spiritual practices in LMIC populations by surveying women on their cultural, traditional, and spiritual practices that they believe help them in various aspects, including mental health, pregnancy outcomes, etc.
- Consider geography-specific and context-specific (e.g., humanitarian crisis in conflict situations) studies. Develop inclusive research protocols with appropriate outcome measures to assess efficacy and safety.
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Identify historically safe and efficacious traditional, cultural, and spiritual practices in LMIC populations by surveying older women on no longer practiced/historical cultural, traditional, and spiritual practices that they believe helped them in various aspects, including mental health, pregnancy outcomes, etc.
- Consider geography-specific and context-specific (e.g., humanitarian crisis in conflict situations) studies. Develop robust trial protocols with outcome measures to assess efficacy and safety.
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Achieve region/country-specific WHO endorsement of identified traditional, cultural, and spiritual practices and document endorsements in a central data repository of practices globally