Resources

Sex Differences in Tolerability to Anti-Programmed Cell Death Protein 1 Therapy in Patients with Metastatic Melanoma and Non-Small Cell Lung Cancer: Are We All Equal?

Duma, N. et al.

Provides information on sex differences in immune-related adverse events from anti-PD-1 therapy in metastatic melanoma and NSCLC, highlighting higher risk in women.

Sex Differences in Traumatic Brain Injury: What We Know and What We Should Know

Gupte, R. et al.

Summarizes current knowledge and research gaps on sex differences in traumatic brain injury outcomes, comparing human and animal studies to guide future research and clinical care. Note: This summary is based on the abstract and main sections; the full article contains more detailed data.

Sex hormones and immune regulation in ovarian cancer

Zhao et al.

Reviews the interplay between sex hormones and immune regulation in ovarian cancer, detailing mechanisms, therapeutic implications, and future research directions.

Sex influence on cancer immunotherapy efficacy and safety in advanced non-small cell lung cancer (NSCLC): A Canadian institution real-world experience

Cohen et al.

Summarizes real-world data on sex differences in immunotherapy efficacy and safety for advanced NSCLC, highlighting higher immune-related adverse events in females.

Sex- and Gender-Based Pharmacological Response to Drugs

Mauvais-Jarvis, F. et al.

Summarizes pharmacokinetics, pharmacodynamics, and clinical applications of monoclonal antibodies, providing guidance for therapeutic use and drug development.

Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure

Rathore, S. S. et al.

Provides information on sex-based differences in digoxin therapy for heart failure, showing increased mortality risk in women but not men.

Sex-Based Heterogeneity in Response to Lung Cancer Immunotherapy: A Systematic Review and Meta-Analysis

Conforti, F. et al.

Reviews data on sex-based differences in lung cancer immunotherapy efficacy, showing women benefit more from chemo-immunotherapy combinations than men.

Sex-Related Reporting In Randomised Controlled Trials In Medical Journals

Avery, E., & Clark, J. 

Summarizes global mortality and causes of death data from 1980–2015 to inform health policy, resource allocation, and disease prevention strategies.

Sex, Gender, And The Brain: Towards an Inclusive Research Agenda

Economist Impact

Provides information on sex and gender differences in brain diseases, reviews data on five disorders, and offers recommendations to guide inclusive neurological research.

Sexual Orientation and Gender Identity (SOGI) Inclusion and Gender Equality

World Bank

Provides information on the global legal status, economic impacts, and effective practices for SOGI inclusion to inform development policy and operations.

Sexually Transmitted Infections and Female Reproductive Health

Van Gerwen, O. et al.

Reviews data on the prevalence, impact, and management of non-HIV sexually transmitted infections affecting female reproductive health, including diagnostic and prevention advances worldwide.

Small Vulnerable Newborn Series

The Lancet

Summarizes prevalence, risks, mechanisms, and prevention strategies for small vulnerable newborns to inform global health action and improve outcomes.

Snapshot of the R&D Landscape for Pre-eclampsia

Impact Global Health

Summarizes the current R&D landscape for pre-eclampsia, including medicines, diagnostics, funding, and innovation priorities, to inform research, policy, and advocacy decisions.

Snapshot of the R&D landscape of postpartum haemorrhage devices (2000-2023)

Impact Global Health

Summarizes the R&D landscape, pipeline status, and types of postpartum haemorrhage devices from 2000-2023 to inform innovation and investment decisions.

Standardizing digital biobanks: integrating imaging, genomic, and clinical data for precision medicine

Brancato et al.

Summarizes standardization and integration methods for harmonizing imaging, genomic, and clinical data in digital biobanks to advance precision medicine.

Statement on Sex, Gender, Variations of Sex Characteristics and Sexual Orientation in Health and Medical Research

NHMRC and the Department of Health and Aged Care

Provides information on best practices for considering sex, gender, sex characteristics, and sexual orientation in health research to improve inclusivity and data quality.

Study: Bacterial Infection Tied to Some Endometriosis Cases

Harris, E. 

Summarizes data linking Fusobacterium bacterial infection to some endometriosis cases and reviews antibiotic treatment effects in a mouse model for research purposes.

Studying Both Sexes: A Guiding Principle for Biomedicine

Clayton, J. A. 

Provides information on the rationale and goals of NIH policy requiring consideration of sex as a biological variable in preclinical biomedical research.

Tailoring Rheumatoid Arthritis Treatment Through A Sex And Gender Lens

Carmona et al.

Reviews data on sex and gender differences in rheumatoid arthritis to inform personalized, equitable treatment strategies and highlight research gaps.

The Arrive Guidelines 2.0: Updated Guidelines For Reporting Animal Research

Percie du Sert, N. et al.

Provides updated guidelines (ARRIVE 2.0) for reporting animal research to improve transparency, reproducibility, and methodological rigour in scientific publications.

The Burden of Communicable and Non-Communicable Diseases in Developing Countries

Boutayeb, A. 

Summarizes the burden, causes, and impacts of communicable and non-communicable diseases in developing countries to inform health and development strategies.

The Definition, Prevalence, and Risk Factors for Stress Urinary Incontinence

Luber, K. M. 

Reviews the history, progress, and current considerations for women's inclusion in U.S. clinical trials to inform research, policy, and clinical practice.

The diagnostics landscape for sexually transmitted infections

World Health Organization

Summarizes commercially available diagnostic tests and platforms for major sexually transmitted infections to support programmatic decisions and expanded screening, especially in low-resource settings.

The Direct and Indirect Costs Associated with Endometriosis: A Systematic Literature Review

Soliman, A. M. et al.

Summarizes direct and indirect costs of endometriosis worldwide to inform understanding of its economic burden for healthcare planning and policy.